The Homeric Phthia of the Mycenaean period, capital of the Kingdom of the Myrmidons and of Peleus, father of Achilles, has sometimes been identified with the later city of Pharsalos (Greek: Φάρσαλος), now Farsala. A Cyclopean Wall which protected a city still exists today near modern Farsala, as does a vaulted tomb from that period.
The Pharsalos of the historic era was built over a hillside of the Narthacius mountains at an elevation of some 160 m, where modern Farsala stands. It was one of the main cities in Thessaly and was the capital of the Phthian tetrarch. In the Persian Wars it sided with the Athenians. A distinctive tribe of the city was that of Echecratidon. In the early 4th century BC, the city was a part of the Thessalian Commons. Later, it joined the Macedonian Kingdom under Philip II. The area became a theatre of war where the Aetolians and the Thessalians clashed with the Macedonians, especially during the Second and the Third Macedonian Wars. After the defeat of the Macedonian Kingdom, Pharsalos and the whole area became a part of the Roman Republic. The whole area suffered great destruction during the Roman Civil War. The Battle of Pharsalus took place in 48 BC in the fields of the Pharsalian Plain, where Julius Caesar defeated Pompey.